GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TGFB1 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of TGFB1 mRNA; Ethanol results in increased expression of TGFB1 protein | PMID:11344824 PMID:15147944 PMID:15963989 PMID:26733986 | TGFB1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Ethanol results in decreased expression of TGFB1 protein | PMID:28843478 | TGFB1 | increases activity | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased activity of TGFB1 protein | PMID:21086752 | TGFB1 | increases expression | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased expression of TGFB1 mRNA; Ethanol results in increased expression of TGFB1 protein | PMID:21172400 PMID:22413959 PMID:22446813 PMID:23274713 PMID:35608386 PMID:36085217 | TGFB1 | increases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of TGFB1 mRNA; Ethanol results in increased expression of TGFB1 protein | PMID:28962519 PMID:30319688 | TGFB1 | increases secretion | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Ethanol results in increased secretion of TGFB1 protein | PMID:37271273 | TGFB1 | multiple interactions | ISO | Tgfb1 (Rattus norvegicus) | 6480464 | CTD | 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]; [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] affects the reaction [Ethanol results in increased expression of TGFB1 mRNA]; [Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA; [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of TGFB1 protein; [Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein; [chebulagic acid co-treated with Ethanol] results in increased expression of TGFB1 protein; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein; betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Ethanol affects the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of TGFB1 mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Genistein inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of TGFB1 protein]; Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA]; Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of TGFB1 mRNA]; Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein] | PMID:17223571 PMID:21172400 PMID:22413959 PMID:22446813 PMID:23274713 PMID:28963034 PMID:30543783 PMID:35066094 PMID:35608386 PMID:35872049 PMID:36085217 | TGFB1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of TGFB1 protein; [Ethanol co-treated with Carbon Tetrachloride co-treated with 4-O-methylhonokiol] results in increased expression of TGFB1 mRNA; [Ethanol co-treated with Thioacetamide] results in increased expression of TGFB1 mRNA; [Palmitic Acid co-treated with Ethanol] results in increased secretion of TGFB1 protein; CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TGFB1 mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Resveratrol inhibits the reaction [Ethanol results in increased activity of TGFB1 protein]; Vitamin E inhibits the reaction [Ethanol results in increased activity of TGFB1 protein] | PMID:21086752 PMID:21863215 PMID:28689299 PMID:35066094 PMID:37271273 | | ||||||||||||||||||||||
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