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GENE - TERM ANNOTATION REPORT

RGD ID: 69093
Species: Homo sapiens
RGD Object: Gene
Symbol: HNF4A
Name: hepatocyte nuclear factor 4 alpha
Acc ID: GO:0004879
Term: nuclear receptor activity
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Definition Source(s): GOC:txnOH-2018, PMID:23457262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HNF4AenablesIBAFB:FBgn0015239 or MGI:98216 or PANTHER:PTN000638895 or Rxrb (Rattus norvegicus) or UniProtKB:P19793 or UniProtKB:P24468 or UniProtKB:P28702 or ZFIN:ZDB-GENE-980526-36 or ZFIN:ZDB-GENE-990415-243150520179GO_Central GO_REF:0000033
HNF4AenablesIEAPANTHER:PTHR24083:SF41150520179TreeGrafter GO_REF:0000118
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