GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad4 | decreases expression | ISO | SMAD4 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of SMAD4 mRNA; Doxorubicin results in decreased expression of SMAD4 protein | PMID:18606404 PMID:29803840 | Smad4 | increases expression | ISO | Smad4 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased expression of SMAD4 mRNA | PMID:21337027 | Smad4 | multiple interactions | ISO | SMAD4 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA; [Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein] | PMID:21337027 | | ||||||||||||||||||||||
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