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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:8434
Term: prochloraz
Definition: A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.
Chemical ID: MESH:C045362
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDprochloraz results in increased activity of NR1I2 proteinPMID:16565514
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[NR1I2 protein co-treated with NR1I3 protein co-treated with prochloraz] results in increased expression of CYP1A1 mRNA; [NR1I2 protein co-treated with NR1I3 protein] affects the reaction [prochloraz results in increased expression of CYP2B10 protein]; prochloraz binds to and results in increased activity of NR1I2 proteinPMID:21115097 PMID:28058446 PMID:33049310
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDprochloraz binds to and results in increased activity of NR1I2 proteinPMID:21115097 PMID:33049310
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