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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2multiple interactionsEXP 6480464CTDMifepristone inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]PMID:20599767
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDMifepristone results in increased activity of NR1I2 proteinPMID:26187274
Nr1i2increases activityISONr1i2 (Mus musculus)6480464CTDMifepristone results in increased activity of NR1I2 proteinPMID:15456840
Nr1i2increases expressionISONr1i2 (Mus musculus)6480464CTDMifepristone results in increased expression of NR1I2 mRNAPMID:14570758
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Mifepristone binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Mifepristone results in increased expression of CYP3A4 mRNA]PMID:12235278 PMID:14570758 PMID:16054614 PMID:17041008
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