Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:5063
Term: fipronil
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
Chemical ID: MESH:C082360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDfipronil results in decreased expression of NR1I2 mRNAPMID:27091632
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDfipronil results in increased activity of NR1I2 proteinPMID:16565514 PMID:20143881 PMID:28728110
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDNR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of ABCC3 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of CES2A mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of CYP3A11 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of GSTA2 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of SLCO1A4 mRNA]PMID:23962444
Go Back to source page   Continue to Ontology report