GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | decreases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | fipronil results in decreased expression of NR1I2 mRNA | PMID:27091632 | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | fipronil results in increased activity of NR1I2 protein | PMID:16565514 PMID:20143881 PMID:28728110 | Nr1i2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of ABCC3 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of CES2A mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of CYP3A11 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of GSTA2 mRNA]; NR1I2 gene mutant form inhibits the reaction [fipronil results in increased expression of SLCO1A4 mRNA] | PMID:23962444 | |
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