GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jak1 | decreases activity | ISO | JAK1 (Homo sapiens) | 6480464 | CTD | tofacitinib results in decreased activity of JAK1 protein | PMID:24883332 | Jak1 | multiple interactions | ISO | JAK1 (Homo sapiens) | 6480464 | CTD | tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein] | PMID:21548952 PMID:23968543 | |
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