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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in decreased expression of TGFB1 mRNA; Raloxifene Hydrochloride results in decreased expression of TGFB1 protein modified formPMID:32947957
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDRaloxifene Hydrochloride results in decreased expression of TGFB1 mRNAPMID:31583774
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDRaloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]PMID:31583774
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDRaloxifene Hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]PMID:15920148
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