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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69038
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFBP1
Name: insulin like growth factor binding protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IGFBP1 mRNA; Benzo(a)pyrene results in increased expression of IGFBP1 proteinPMID:16269432 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:26238291 PMID:32234424 PMID:33278487
IGFBP1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of IGFBP1 exon; Benzo(a)pyrene results in increased methylation of IGFBP1 promoterPMID:27901495
IGFBP1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGFBP1 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGFBP1 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGFBP1 mRNAPMID:17690111
IGFBP1decreases expressionISOIgfbp1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGFBP1 mRNAPMID:19770486
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