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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69029
Species: Homo sapiens
RGD Object: Gene
Symbol: INSR
Name: insulin receptor
Acc ID: CHEBI:17158
Term: methylglyoxal
Definition: A 2-oxo aldehyde derived from propanal.
Chemical ID: MESH:D011765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSRdecreases phosphorylationEXP 6480464CTDPyruvaldehyde results in decreased phosphorylation of INSR proteinPMID:22917016
INSRmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]PMID:22917016
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