Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005
Species: Mus musculus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionEXP 6480464CTDIsoproterenol results in increased expression of STAT3 mRNAPMID:21335049
Stat3multiple interactionsEXP 6480464CTDSTAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]]PMID:31712309
Stat3affects localizationISOStat3 (Rattus norvegicus)6480464CTDIsoproterenol affects the localization of STAT3 proteinPMID:19299911
Stat3increases expressionISOStat3 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of STAT3; Isoproterenol results in increased expression of STAT3 proteinPMID:19299911 PMID:29355689
Stat3increases phosphorylationISOStat3 (Rattus norvegicus)6480464CTDIsoproterenol results in increased phosphorylation of STAT3 proteinPMID:25080425
Stat3multiple interactionsISOStat3 (Rattus norvegicus)6480464CTD[Isoproterenol co-treated with POSTN protein] results in decreased expression of STAT3 mRNA; Betaine promotes the reaction [Isoproterenol results in increased phosphorylation of STAT3 protein]; Cyclosporine inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]; Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein; Verapamil inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]PMID:19299911 PMID:25080425 PMID:30303030
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDSTAT3 protein affects the reaction [BMP10 protein results in decreased susceptibility to Isoproterenol]PMID:31712309
Go Back to source page   Continue to Ontology report