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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1Rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTDHonghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein]]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GATA4 protein]]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NPPA protein]]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NPPB protein]]; Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of IGF1R protein; tyrphostin AG 1024 inhibits the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1R protein]]PMID:31486215 PMID:31714667
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