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GENE - TERM ANNOTATION REPORT

RGD ID: 68979
Species: Mus musculus
RGD Object: Gene
Symbol: Clu
Name: clusterin
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Clu ISOCLU (Homo sapiens)8903235RGD  
Clu ISOCLU (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:19734902 PMID:19734903 PMID:21460841
Clu ISOCLU (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Alzheimer diseasePMID:28492532 PMID:29476165
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