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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:690086480464CTDTetradecanoylphorbol Acetate results in increased expression of IL13 mRNA

PMID:10428506
multiple interactionsISORGD:690086480464CTD[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein

[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein

[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein

[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein

[IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]

[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]

[IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]

[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA

fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA]

IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein]

IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]

leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]

PMID:21331654, PMID:26091108
multiple interactionsISORGD:690096480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA

lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA]

PMID:22398747
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.