GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:690096480464CTDTetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL13 protein]

Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL13 protein]

Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL13 promoter]

PMID:19654925, PMID:21804081, PMID:22491429
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.