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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:10112
Term: zileuton
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Chemical ID: MESH:C063449
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDzileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]

zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]

zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]

zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]

PMID:12654629
affects expressionISORGD:690096480464CTDzileuton affects the expression of IL13 protein

PMID:15927844
multiple interactionsISORGD:690096480464CTDzileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]

PMID:12794006
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.