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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68649
Species: Homo sapiens
RGD Object: Gene
Symbol: PDE10A
Name: phosphodiesterase 10A
Acc ID: CHEBI:16356
Term: 3',5'-cyclic GMP
Definition: A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.
Chemical ID: MESH:D006152
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PDE10Aincreases hydrolysisEXP 6480464CTDPDE10A protein results in increased hydrolysis of Cyclic GMPPMID:10373451
PDE10Amultiple interactionsEXP 6480464CTDCyclic AMP inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP]; Cyclic GMP inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP]PMID:10373451
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