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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68617
Species: Mus musculus
RGD Object: Gene
Symbol: Dlc1
Name: deleted in liver cancer 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dlc1affects expressionISODlc1 (Rattus norvegicus)6480464CTDEstradiol affects the expression of DLC1 mRNAPMID:32145629
Dlc1affects expressionISODLC1 (Homo sapiens)6480464CTDEstradiol affects the expression of DLC1 mRNAPMID:22574217
Dlc1increases expressionISODlc1 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of DLC1 mRNAPMID:35192832
Dlc1increases expressionISODLC1 (Homo sapiens)6480464CTDEstradiol results in increased expression of DLC1 mRNAPMID:19619570 PMID:24758408
Dlc1multiple interactionsISODLC1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DLC1 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of DLC1 mRNA; EGF protein inhibits the reaction [Estradiol results in increased expression of DLC1 mRNA]PMID:19619570 PMID:24758408 PMID:30165855
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