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GENE - TERM ANNOTATION REPORT

RGD ID: 68600
Species: Mus musculus
RGD Object: Gene
Symbol: Lrp2
Name: low density lipoprotein receptor-related protein 2
Acc ID: GO:0006898
Term: receptor-mediated endocytosis
Definition: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
Definition Source(s): GOC:mah, ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp2 ISOLrp2 (Rattus norvegicus)9068941RGD PMID:11595644 REF_RGD_ID:628443
Lrp2involved_inIBAPANTHER:PTN008580772 or UniProtKB:P98164 or Lrp2 (Rattus norvegicus) or MGI:95794 or ZFIN:ZDB-GENE-050119-22290270GO_Central GO_REF:0000033
Lrp2acts_upstream_of_or_withinIMP 2290270MGI PMID:10052453

PMID:10052453
Lrp2involved_inISOLrp2 (Rattus norvegicus)2290270MGI GO_REF:0000096 MGI:4417868
Lrp2involved_inISOUniProtKB:P981642290270MGI GO_REF:0000119 MGI:4834177
Lrp2involved_inIDA 2290270UniProt MGI:3525818 PMID:15623804

MGI:3525818 PMID:15623804
Lrp2involved_inIMP 2290270UniProt MGI:3711604 PMID:17462596 MGI:3783915 PMID:18174160 MGI:5908346 PMID:12724130 MGI:5908471 PMID:28659595

MGI:3711604 MGI:3783915 MGI:5908346 MGI:5908471 PMID:12724130 PMID:17462596 PMID:18174160 PMID:28659595
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