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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68573
Species: Mus musculus
RGD Object: Gene
Symbol: Alas1
Name: aminolevulinic acid synthase 1
Acc ID: CHEBI:28222
Term: 1,2,4-trichlorobenzene
Definition: A trichlorobenzene with chloro substituents at positions 1, 2 and 4.
Chemical ID: MESH:C009947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alas1increases activityISOAlas1 (Rattus norvegicus)6480464CTD1,2,4-trichlorobenzene results in increased activity of ALAS1 proteinPMID:11996131 PMID:6895089
Alas1multiple interactionsISOAlas1 (Rattus norvegicus)6480464CTDButhionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein]PMID:11996131
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