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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:48958
Term: 1,1'-azobis(N,N-dimethylformamide)
Definition: A monoazo compound that has formula C6H12N4O2.
Chemical ID: MESH:D003958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORincreases activityEXP 6480464CTDDiamide results in increased activity of MTOR proteinPMID:16183647
MTORmultiple interactionsEXP 6480464CTD[Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Diamide inhibits the reaction [MTOR protein binds to RPTOR protein]; MTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]PMID:16183647
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