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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORaffects methylationEXP 6480464CTDArsenic affects the methylation of MTOR genePMID:25304211
MTORincreases expressionEXP 6480464CTDArsenic results in increased expression of MTOR protein; Arsenic results in increased expression of MTOR protein modified formPMID:25586904 PMID:29248574
MTORmultiple interactionsEXP 6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein; OSGIN1 protein promotes the reaction [Arsenic results in increased expression of MTOR protein modified form]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]; UCA1 mRNA promotes the reaction [Arsenic results in increased expression of MTOR protein modified form]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]PMID:29248574 PMID:32802178
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