Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	68533
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MTOR
Name:	mechanistic target of rapamycin kinase

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MTOR	affects phosphorylation	EXP		6480464	CTD	Cisplatin affects the phosphorylation of MTOR protein	PMID:24799992
MTOR	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of MTOR protein	PMID:26201060
MTOR	decreases phosphorylation	EXP		6480464	CTD	Cisplatin results in decreased phosphorylation of MTOR protein	PMID:18058806 PMID:30550853 PMID:32762018
MTOR	increases phosphorylation	EXP		6480464	CTD	Cisplatin results in increased phosphorylation of MTOR protein	PMID:20935474
MTOR	multiple interactions	EXP		6480464	CTD	[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in decreased expression of MTOR protein; [cordycepin co-treated with Cisplatin] results in decreased phosphorylation of MTOR protein; Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]; Sirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]; Topotecan inhibits the reaction [Cisplatin results in increased phosphorylation of MTOR protein]	PMID:18058806 PMID:20935474 PMID:21191146 PMID:21358348 PMID:24799992 PMID:33520990
MTOR	increases expression	ISO	Mtor (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of MTOR protein	PMID:32777238
MTOR	multiple interactions	ISO	Mtor (Rattus norvegicus)	6480464	CTD	Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MTOR protein]	PMID:32777238

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