GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MTOR | affects phosphorylation | EXP | | 6480464 | CTD | Cisplatin affects the phosphorylation of MTOR protein | PMID:24799992 | MTOR | decreases expression | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of MTOR protein | PMID:26201060 | MTOR | decreases phosphorylation | EXP | | 6480464 | CTD | Cisplatin results in decreased phosphorylation of MTOR protein | PMID:18058806 PMID:30550853 PMID:32762018 | MTOR | increases phosphorylation | EXP | | 6480464 | CTD | Cisplatin results in increased phosphorylation of MTOR protein | PMID:20935474 | MTOR | multiple interactions | EXP | | 6480464 | CTD | [Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in decreased expression of MTOR protein; [cordycepin co-treated with Cisplatin] results in decreased phosphorylation of MTOR protein; Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]; Cisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]; Sirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]; Topotecan inhibits the reaction [Cisplatin results in increased phosphorylation of MTOR protein] | PMID:18058806 PMID:20935474 PMID:21191146 PMID:21358348 PMID:24799992 PMID:33520990 | MTOR | increases expression | ISO | Mtor (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in increased expression of MTOR protein | PMID:32777238 | MTOR | multiple interactions | ISO | Mtor (Rattus norvegicus) | 6480464 | CTD | Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MTOR protein] | PMID:32777238 | |
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