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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68520
Species: Mus musculus
RGD Object: Gene
Symbol: Sigmar1
Name: sigma non-opioid intracellular receptor 1
Acc ID: CHEBI:73297
Term: SCH 23390
Definition: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 7 and a hydroxy substituent at position 8.
Chemical ID: MESH:C534628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sigmar1multiple interactionsISOSIGMAR1 (Homo sapiens)6480464CTDSCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]PMID:20956312
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