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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68518
Species: Mus musculus
RGD Object: Gene
Symbol: Hal
Name: histidine ammonia lyase
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Haldecreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of HAL mRNAPMID:16221962 PMID:18445702 PMID:20059764 PMID:20813756 PMID:23811191 PMID:25270620
Halmultiple interactionsEXP 6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HAL mRNA; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of HAL mRNA]PMID:19710929 PMID:20059764
Halaffects expressionISOHal (Rattus norvegicus)6480464CTDpirinixic acid affects the expression of HAL mRNAPMID:19483382
Haldecreases expressionISOHal (Rattus norvegicus)6480464CTDpirinixic acid results in decreased expression of HAL mRNAPMID:17164430 PMID:19162173 PMID:32741898
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