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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68516
Species: Mus musculus
RGD Object: Gene
Symbol: Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrataffects response to substanceEXP 6480464CTDLRAT gene mutant form affects the susceptibility to bisphenol APMID:28123100
Lratincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LRAT mRNAPMID:35598803
Lratmultiple interactionsEXP 6480464CTD[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in decreased expression of CYP2C39 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP4A10 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA; [LRAT gene mutant form affects the susceptibility to bisphenol A] which results in decreased expression of CYP2B10 mRNA; [LRAT gene mutant form affects the susceptibility to bisphenol A] which results in decreased expression of FMO3 mRNAPMID:28123100
Lrataffects expressionISOLrat (Rattus norvegicus)6480464CTDbisphenol A affects the expression of LRAT mRNAPMID:25181051
Lratdecreases expressionISOLrat (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of LRAT mRNAPMID:34947998
Lratmultiple interactionsISOLrat (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of LRAT mRNAPMID:26496021
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