Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68515
Species: Homo sapiens
RGD Object: Gene
Symbol: LRAT
Name: lecithin retinol acyltransferase
Acc ID: CHEBI:32095
Term: retinyl acetate
Definition: An acetate ester that has formula C22H32O2.
Chemical ID: MESH:C009166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LRATmultiple interactionsISOLrat (Mus musculus)6480464CTD[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in decreased expression of CYP2C39 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP4A10 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA; retinol acetate inhibits the reaction [LRAT gene mutant form results in decreased susceptibility to Thioacetamide]PMID:24614237 PMID:28123100
Go Back to source page   Continue to Ontology report