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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68509
Species: Homo sapiens
RGD Object: Gene
Symbol: SULT1A2
Name: sulfotransferase family 1A member 2
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SULT1A2increases activityEXP 6480464CTDSULT1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:21900212 PMID:22006426
SULT1A2increases metabolic processingEXP 6480464CTDSULT1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:26940682
SULT1A2multiple interactionsEXP 6480464CTD[SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [SULT1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adductPMID:22006426 PMID:26940682
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