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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68498
Species: Mus musculus
RGD Object: Gene
Symbol: Dhodh
Name: dihydroorotate dehydrogenase
Acc ID: CHEBI:68540
Term: teriflunomide
Definition: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Chemical ID: MESH:C072876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhodhmultiple interactionsEXP 6480464CTDteriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]PMID:11248707
Dhodhdecreases activityISODhodh (Rattus norvegicus)6480464CTDteriflunomide results in decreased activity of DHODH proteinPMID:9776318 PMID:9802339
Dhodhdecreases activityISODHODH (Homo sapiens)6480464CTDteriflunomide results in decreased activity of DHODH proteinPMID:9802339
Dhodhdecreases expressionISODHODH (Homo sapiens)6480464CTDteriflunomide results in decreased expression of DHODH mRNAPMID:29427785
Dhodhmultiple interactionsISODhodh (Rattus norvegicus)6480464CTDteriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]PMID:11248707 PMID:9776318 PMID:9802339
Dhodhmultiple interactionsISODHODH (Homo sapiens)6480464CTDteriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]PMID:11248707
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