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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68476
Species: Mus musculus
RGD Object: Gene
Symbol: Fads2
Name: fatty acid desaturase 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fads2decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of FADS2 mRNAPMID:28973697
Fads2decreases expressionISOFADS2 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of FADS2 mRNAPMID:11916926
Fads2multiple interactionsISOFads2 (Rattus norvegicus)6480464CTDtroglitazone inhibits the reaction [Dietary Sucrose results in increased activity of FADS2 protein]; troglitazone inhibits the reaction [Dietary Sucrose results in increased expression of FADS2 mRNA]PMID:15763435
Fads2multiple interactionsISOFADS2 (Homo sapiens)6480464CTD[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Cholesterol Esters; [troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Phospholipids; [troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of TriglyceridesPMID:11916926
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