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GENE - TERM ANNOTATION REPORT

RGD ID: 68460
Species: Homo sapiens
RGD Object: Gene
Symbol: THOP1
Name: thimet oligopeptidase 1
Acc ID: GO:0004222
Term: metalloendopeptidase activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Definition Source(s): GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THOP1enablesIBAMGI:1354165 or PANTHER:PTN000211184 or Nln (Rattus norvegicus) or SGD:S000000562 or SGD:S000001617150520179GO_Central GO_REF:0000033
THOP1enablesIEAInterPro:IPR001567 or InterPro:IPR045090150520179InterPro GO_REF:0000002
THOP1enablesTAS 150520179PINC PMID:7639763

PMID:7639763 Reactome:R-HSA-8940641
THOP1enablesIEAPANTHER:PTHR11804:SF50150520179TreeGrafter GO_REF:0000118
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