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GENE - TERM ANNOTATION REPORT

RGD ID: 68431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn5
Name: claudin 5
Acc ID: GO:0005923
Term: bicellular tight junction
Definition: An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
Definition Source(s): GOC:mah, ISBN:0815332181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:686441624291RGD PMID:25816133, PMID:9892664
 ISORGD:686451624291RGD MGI:MGI:5310681, MGI:MGI:5507964, PMID:22275141, PMID:22946046
 ISSUniProtKB:Q9Z0G91600115UniProtGO_REF:0000024

GO_REF:0000024
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.