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GENE - TERM ANNOTATION REPORT

RGD ID: 68424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Acc ID: GO:0007268
Term: chemical synaptic transmission
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:jl, MeSH:D009435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dlg4involved_inIBAFB:FBgn0001624 or MGI:1344351 or PANTHER:PTN0005635691600115GO_CentralGO_REF:0000033

GO_REF:0000033
Dlg4involved_inIEAInterPro:IPR0163131600115InterProGO_REF:0000002

GO_REF:0000002
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