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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dlg4affects localizationEXP 6480464CTDOxidopamine affects the localization of DLG4 proteinPMID:15703272
Dlg4decreases expressionEXP 6480464CTDOxidopamine results in decreased expression of DLG4 mRNA; Oxidopamine results in decreased expression of DLG4 proteinPMID:15703272 PMID:34302886
Dlg4multiple interactionsEXP 6480464CTD[Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 protein; Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of DLG4 protein]PMID:15703272 PMID:34302886
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