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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dlg4decreases expressionISODlg4 (Mus musculus)6480464CTDKetamine results in decreased expression of DLG4 proteinPMID:31470060 PMID:36172893
Dlg4increases expressionISODlg4 (Mus musculus)6480464CTDKetamine results in increased expression of DLG4 proteinPMID:33022268
Dlg4multiple interactionsISODlg4 (Mus musculus)6480464CTDKetamine inhibits the reaction [Corticosterone results in decreased expression of DLG4 protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of DLG4 protein]PMID:33022268 PMID:33872575
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