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GENE - TERM ANNOTATION REPORT

RGD ID: 68422
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn1
Name: claudin 1
Acc ID: DOID:9001620
Term: Leukoaraiosis
Definition: Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.
Definition Source(s): MESH:D049292
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn1 ISOCLDN1 (Homo sapiens)11344876RGDDNA:SNPs: :rs17501010, rs893051,rs9290927(human) 
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