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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68422
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn1
Name: claudin 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn1multiple interactionsISOCLDN1 (Homo sapiens)6480464CTDLithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]PMID:31472180
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