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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68422
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn1
Name: claudin 1
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn1decreases expressionISOCLDN1 (Homo sapiens)6480464CTDZearalenone results in decreased expression of CLDN1 proteinPMID:28865950
Cldn1multiple interactionsISOCLDN1 (Homo sapiens)6480464CTD[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 proteinPMID:28865950 PMID:28935499
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