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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dio2
Name: iodothyronine deiodinase 2
Acc ID: CHEBI:28774
Term: 3,3',5'-triiodothyronine
Definition: An iodothyronine that has formula C15H12I3NO4.
Chemical ID: MESH:D014285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio2decreases activityISODIO2 (Homo sapiens)6480464CTDTriiodothyronine, Reverse results in decreased activity of DIO2 proteinPMID:26004626
Dio2multiple interactionsISODIO2 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]]PMID:26004626
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