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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dio2
Name: iodothyronine deiodinase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio2multiple interactionsEXP 6480464CTDEstradiol promotes the reaction [4,4'-hexafluorisopropylidene diphenol results in decreased expression of DIO2 mRNA]; Estradiol promotes the reaction [bisphenol A results in decreased expression of DIO2 mRNA]PMID:30099086
Dio2increases expressionISODio2 (Mus musculus)6480464CTDEstradiol results in increased expression of DIO2 mRNAPMID:19484750
Dio2increases expressionISODIO2 (Homo sapiens)6480464CTDEstradiol results in increased expression of DIO2 mRNAPMID:21795739
Dio2multiple interactionsISODIO2 (Homo sapiens)6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of DIO2 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of DIO2 mRNAPMID:17404688 PMID:20660070 PMID:20823114
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