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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dio2
Name: iodothyronine deiodinase 2
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio2increases chemical synthesisEXP 6480464CTDDIO2 protein results in increased chemical synthesis of TriiodothyroninePMID:17615150
Dio2increases expressionEXP 6480464CTDTriiodothyronine results in increased expression of DIO2 mRNAPMID:25646720
Dio2decreases expressionISODio2 (Mus musculus)6480464CTDTriiodothyronine results in decreased expression of DIO2 mRNAPMID:34571837
Dio2multiple interactionsISODio2 (Mus musculus)6480464CTD[Chlorpyrifos co-treated with Triiodothyronine] results in decreased expression of DIO2 mRNA; [Ethylenethiourea co-treated with Triiodothyronine] results in decreased expression of DIO2 mRNAPMID:34571837
Dio2multiple interactionsISODIO2 (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]PMID:17327447 PMID:23397585 PMID:26004626
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