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GENE - TERM ANNOTATION REPORT

RGD ID: 68404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: GO:0071456
Term: cellular response to hypoxia
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Definition Source(s): GOC:mah
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1 IEP 11041576RGD  
Epas1involved_inISOEPAS1 (Homo sapiens)1624291RGD PMID:11573933

PMID:11573933
Epas1involved_inIEAUniProtKB:Q99814 or ensembl:ENSP000002637341600115EnsemblGO_REF:0000107

GO_REF:0000107
Epas1involved_inIBAFB:FBgn0266411 or MGI:106918 or PANTHER:PTN000548864 or Hif1a (Rattus norvegicus) or Epas1 (Rattus norvegicus) or UniProtKB:Q16665 or UniProtKB:Q998141600115GO_CentralGO_REF:0000033

GO_REF:0000033
Epas1involved_inIEAPANTHER:PTHR23043:SF81600115TreeGrafterGO_REF:0000118

GO_REF:0000118
Epas1involved_inISSUniProtKB:Q998141600115UniProtGO_REF:0000024

GO_REF:0000024
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