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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alas1
Name: 5'-aminolevulinate synthase 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alas1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of ALAS1 mRNAPMID:19162173
Alas1affects expressionISOALAS1 (Homo sapiens)6480464CTDPhenobarbital affects the expression of ALAS1 mRNAPMID:19159669
Alas1decreases expressionISOAlas1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of ALAS1 mRNAPMID:19270015
Alas1increases expressionISOALAS1 (Homo sapiens)6480464CTDPhenobarbital results in increased expression of ALAS1 mRNAPMID:19084549
Alas1increases expressionISOAlas1 (Mus musculus)6480464CTDPhenobarbital results in increased expression of ALAS1 mRNAPMID:19270015 PMID:22859313 PMID:23091169 PMID:25270620
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