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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:9352
Term: sulindac
Definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Chemical ID: MESH:D013467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDSulindac results in decreased expression of CCND1 protein

PMID:11504793, PMID:11593435, PMID:17292881, PMID:18291362
decreases expressionISORGD:685576480464CTDSulindac results in decreased expression of CCND1 protein

PMID:12584176, PMID:15020200
multiple interactionsISORGD:685566480464CTDCTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein], Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]

PMID:15489888, PMID:18291362
multiple interactionsISORGD:685576480464CTD[Sulindac co-treated with Plant Extracts] results in decreased expression of CCND1 protein

PMID:12351151
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.