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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein

PMID:29653943
multiple interactionsEXP 6480464CTDDDIT3 protein affects the reaction [6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein], SIRT1 protein inhibits the reaction [6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein]

PMID:29653943
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.