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RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685576480464CTDwortmannin results in decreased expression of CCND1 protein

multiple interactionsISORGD:685566480464CTDwortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA], wortmannin inhibits the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased expression of CCND1 protein]

PMID:19801633, PMID:28321046
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.