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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:47344
Term: alvocidib
Definition: A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
Chemical ID: MESH:C077990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:685566480464CTDalvocidib results in decreased activity of CCND1 protein

PMID:10441105
decreases expressionISORGD:685566480464CTDalvocidib results in decreased expression of CCND1 protein

PMID:12517783, PMID:12589031, PMID:16905211, PMID:9802881, PMID:9829756
decreases expressionISORGD:685576480464CTDalvocidib results in decreased expression of CCND1 protein

PMID:12734434
multiple interactionsISORGD:685566480464CTD[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of CCND1 protein

PMID:15634644
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.