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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionEXP 6480464CTDZinc results in decreased expression of CCND1 mRNAPMID:17074742
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDZinc deficiency results in decreased expression of CCND1 protein; Zinc results in decreased expression of CCND1 proteinPMID:19913001 PMID:21600978
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDZinc results in increased expression of CCND1 mRNAPMID:19071009
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]PMID:21600978
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]]PMID:20857495 PMID:26091902
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