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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDeoxycholic Acid results in increased expression of CCND1 mRNA, Deoxycholic Acid results in increased expression of CCND1 protein

PMID:17431217
multiple interactionsEXP 6480464CTD[Deoxycholic Acid results in increased expression of CCND1 protein] which affects the localization of BAX protein, tauroursodeoxycholic acid inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein], TP53 protein affects the reaction [[Deoxycholic Acid results in increased expression of CCND1 protein] which affects the localization of BAX protein], Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein]

PMID:17431217
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.