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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDZinc results in decreased expression of CCND1 mRNA

PMID:17074742
decreases expressionISORGD:685566480464CTDZinc deficiency results in decreased expression of CCND1 protein, Zinc results in decreased expression of CCND1 protein

PMID:19913001, PMID:21600978
increases expressionISORGD:685566480464CTDZinc results in increased expression of CCND1 mRNA

PMID:19071009
multiple interactionsISORGD:685566480464CTDAcetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein], Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]

PMID:21600978
multiple interactionsISORGD:685576480464CTD[Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA, [Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of CCND1 protein, Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of CCND1 protein]

PMID:20857495, PMID:26091902
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.